5 Oral Drugs Commonly Used in Sedation Dentistry

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Various oral sedatives have established efficacy and safety for managing fear and dental anxiety.

Anxiety and fear of going to the dentist persist despite the advancements in modern dentistry. Fortunately, oral sedatives in sedation dentistry have established efficacy and safety for managing dental anxiety. Oral sedatives can keep the patient awake while still having the desired calming effect.

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My sweet daughter has Autism, and was unable to work with a typical dentist. She must be sedated for dental cleanings, which can be scary for both of us. The team here is always very warm and understanding. They’re patient and willing to help us when she is struggling. Dr. Thoms is so helpful and kind. We’ve seen him for several years now, and I trust him and his team completely. Thank you!
I am so impressed with this Place. The staff is super friendly and explains everything in great detail and really takes their time with their patients. I came here after 15+ years of not having Dental insurance or the means to see a Dentist. Needless to say, my teeth were in pretty bad shape, and I needed a deep periodontal cleaning. When I went in for consultation back in February I was totally nervous, anxious had no clue what to expect. I just knew that I needed to a tooth that was falling out pulled and needed to do something about my teeth. After talking with a staff member and Dr. Hoffmann I felt totally at ease. Both my procedures in Feb and May went incredibly well and I woke up from both with an incredible smile. I came back today for follow up and cleaning my Hygienist was awesome I still had some sensitivity around my front teeth and when she noticed I flinched she stopped and said do you need break, or do you want me to put some numbing jell on your front teeth. After we got done, I had a lot of questions about the proper way to floss, what type of tooth paste I should use for sensitive teeth etc and she really took the time to answer all my questions. If you have been putting off dental work because of anxiety, I encourage you to check this place out. The staff truly cares about their clients.
Response from the owner:Thank you for your thoughtful review and kind words. We’re so glad you felt informed, supported, and cared for throughout your visits. Helping patients feel comfortable and confident in their dental care means so much to our team. We truly appreciate your trust!
I went to nervous and 3 to 4 hours later, I essentially woke up in the car on my way home without realizing anything had happened. If you have trauma with previous dental issues, this is the place.
Response from the owner:Thank you for your kind words and for sharing your experience. We’re grateful our team could help provide a comfortable experience and appreciate your trust in us.
Amazing staff from entering to exiting! Thank you all for truly caring and taking the time to explain every step as you go. You are appreciated and I would highly recommend you to everyone!
Response from the owner:Thank you for your kind words and recommendation! We’re so glad you felt cared for and informed throughout your experience. Our team truly appreciates your support!
Extremely friendly and professional Liked the way everything was explained a b d was concerned about my comfort k rt
Response from the owner:Thank you for your kind review! We’re so glad you felt comfortable and well informed during your visit. Our team truly appreciates your support!

There are many types of sedation used in sedation dentistry, ranging from mild sedation administered through a breathing mask to general anesthesia administered intravenously. There is a range of oral sedatives between these two options that can keep the patient awake while still having the desired calming effect.

If you are not sure what substances are used during sedation dentistry, here is a list of the most common oral drugs that a sedation dentist may prescribe for your dental treatment.

Midazolam (Versed)

Midazolam is the most commonly used drug in oral sedation dentistry, and it is generally considered very safe, inducing only a mild form of sedation. One precaution usually required when administering midazolam is to reschedule patients with respiratory infections for the day of the intervention, as this drug has a greater impact on the respiratory tract than on the circulatory system.

Diazepam (Valium)

One of the drugs almost everyone has heard about is diazepam (Valium). It is used in various medical interventions, including as an oral sedative for dental surgery. The time it takes for diazepam to remain in a 50% concentration in the patient’s system is longer than with other drugs, making it the preferred choice for extended, complex dental operations.

Triazolam (Halcion)

For patients who have a hard time going to the dentist because of their associated anxiety, triazolam is often the doctor’s choice. Primarily a drug that fights insomnia, it has an effect on the patient’s anxiety level and helps them go through the procedure without remembering it afterward, which allows them to be unaffected by their dental anxiety and come back next time.

Lorazepam (Ativan)

Another benzodiazepine with amnesic properties, like diazepam, lorazepam is very useful in patients with anxiety, allowing them to go through their dental treatment without the effects of their anxiety.

Hydroxyzine (Vistaril)

Hydroxyzine is an antihistamine that also acts on the patient’s anxiety levels. It is used short-term to treat anxiety or help a patient feel sleepy or relaxed before a dental procedure.

As you can see, there are many drug options if your St. Louis sedation dentist recommends oral sedation for your dental procedure. Which drug will be chosen depends on how long it takes for the medicine to get out of your system, your allergies and sensitivities, and what is needed from the sedation itself.

St. Louis Sedation Dentistry

For over 30 years, the Dental Anesthesia Center has combined sleep dentistry and cutting-edge technology to help patients overcome the fear and health issues that have prevented them from seeking dental care. We work hard to make you feel at ease by providing exceptional patient care in a relaxed, convenient atmosphere.

Click here to learn more about Sedation Dentistry

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The first two board-certified Dentist Anesthesiologists in the state of Missouri.

Updated: July 14, 2025

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