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5 Oral Drugs Commonly Used in Sedation Dentistry

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Various oral sedatives have established efficacy and safety for managing fear and dental anxiety.

Anxiety and fear of going to the dentist persist despite the advancements in modern dentistry. Fortunately, oral sedatives in sedation dentistry have established efficacy and safety for managing dental anxiety. Oral sedatives can keep the patient awake while still having the desired calming effect.

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Best Dentists in St. Louis. Really a great dental experience. I have used this office for regular dental care, cavities, crowns, and cosmetic dentistry. Teeth look great.
Response from the owner:Christopher we apologize for the belated response. We are very pleased to hear you have a great dental experience with our office! Thank you for your kind words. We look forward to seeing you at your next dental appointment!
Amazing
Response from the owner:Thank you so much! We truly appreciate the amazing review! ⭐️
Thanks Laina for making my visit great. You are the best.
Response from the owner:Thank you for your kind words! We’ll be sure to share your appreciation with Laina. 😊
Dr. Behl! I cannot recommend Dr. Maris Behl enough. If you have dental anxiety, she is truly the kind of dentist you hope to find. If teeth could be wrapped in pillows and protected by flying unicorns, Dr. Behl would somehow make it happen. I have significant anxiety around dental procedures and have needed deeper sedation for dental work in the past. From the beginning, Dr. Behl took the time to listen to my concerns and made me feel genuinely heard rather than dismissed or rushed. She created such a sense of trust and safety that I was eventually able to have my dental work done with only nitrous instead of full sedation, which is something I honestly didn’t think I would be comfortable doing. During my crown placement, she explained what she was doing throughout the procedure, which made an enormous difference in keeping me calm. She also took the time to address a filling that had been bothering me for what felt like forever — and she actually fixed the problem. What stands out most about Dr. Behl is how safe I feel in her care. She is compassionate, patient, communicative, and incredibly attentive to how her patients are feeling. For someone with dental anxiety, that combination is invaluable. Finding a dentist I trust this much has completely changed my experience with dental care. I am incredibly grateful to Dr. Behl and would recommend her without hesitation, especially to anyone who has dental anxiety or has struggled to feel comfortable receiving dental treatment.
Response from the owner:Thank you for such incredibly kind words! We’ll be sure to pass this along to Dr. Behl. We’re pretty sure the flying unicorns are going to be the part she remembers most! 🦄💙 We’re so glad our team could help make your experience a more comfortable one.
Dr Thoms and his team are phenomenal. No question, the absolute best possible option for my child when he needed work done while sleeping (age based). While this option is not inexpensive, this set up of have anesthesiology in-house allowed us to get his mouth healthy when a traditional pediatric dentist could/would not. I am a parent that asks a lot of questions on behalf of my toddler’s care and at no point did I feel judged for this, nor was I rushed during my evaluation process during the consultation. Although the procedure is not one I would like to repeat for my child, my husband and I were both so pleased with how well Dr. Thoms communicated and how he clearly cared for our son’s wellbeing (both physical and emotional during a less than comfortable visit). Cannot recommend the back of house team more highly. My one detraction is the FOH staff (not everyone) were not nearly as pleasant. I would like to communicate that while their day-to-day is very routine for them, being in that office as a parent is very scary for some people in their office and a little bit of kindness goes along way. I do recall, having a very pleasant conversation with Rebecca, but otherwise everyone else was on the apathetic side, in my personal opinion. That said you’ll notice that I still am leaving a five star review because the dental staff really just knocked out of the park, but as a parent I want to encourage you to look past any rudeness you may experience over email or on the phone because Dr. Thom’s is really that excellent.
Response from the owner:Thank you for taking the time to share such thoughtful feedback. We’re grateful to hear that our team provided compassionate, attentive care and took the time to answer your questions throughout the process. We also appreciate your comments regarding your experience with our front office team and will certainly share your feedback. Your kind words mean so much to us!

There are many types of sedation used in sedation dentistry, ranging from mild sedation administered through a breathing mask to general anesthesia administered intravenously. There is a range of oral sedatives between these two options that can keep the patient awake while still having the desired calming effect.

If you are not sure what substances are used during sedation dentistry, here is a list of the most common oral drugs that a sedation dentist may prescribe for your dental treatment.

Midazolam (Versed)

Midazolam is the most commonly used drug in oral sedation dentistry, and it is generally considered very safe, inducing only a mild form of sedation. One precaution usually required when administering midazolam is to reschedule patients with respiratory infections for the day of the intervention, as this drug has a greater impact on the respiratory tract than on the circulatory system.

Diazepam (Valium)

One of the drugs almost everyone has heard about is diazepam (Valium). It is used in various medical interventions, including as an oral sedative for dental surgery. The time it takes for diazepam to remain in a 50% concentration in the patient’s system is longer than with other drugs, making it the preferred choice for extended, complex dental operations.

Triazolam (Halcion)

For patients who have a hard time going to the dentist because of their associated anxiety, triazolam is often the doctor’s choice. Primarily a drug that fights insomnia, it has an effect on the patient’s anxiety level and helps them go through the procedure without remembering it afterward, which allows them to be unaffected by their dental anxiety and come back next time.

Lorazepam (Ativan)

Another benzodiazepine with amnesic properties, like diazepam, lorazepam is very useful in patients with anxiety, allowing them to go through their dental treatment without the effects of their anxiety.

Hydroxyzine (Vistaril)

Hydroxyzine is an antihistamine that also acts on the patient’s anxiety levels. It is used short-term to treat anxiety or help a patient feel sleepy or relaxed before a dental procedure.

As you can see, there are many drug options if your St. Louis sedation dentist recommends oral sedation for your dental procedure. Which drug will be chosen depends on how long it takes for the medicine to get out of your system, your allergies and sensitivities, and what is needed from the sedation itself.

St. Louis Sedation Dentistry

For over 30 years, the Dental Anesthesia Center has combined sleep dentistry and cutting-edge technology to help patients overcome the fear and health issues that have prevented them from seeking dental care. We work hard to make you feel at ease by providing exceptional patient care in a relaxed, convenient atmosphere.

Click here to learn more about Sedation Dentistry

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The first two board-certified Dentist Anesthesiologists in the state of Missouri.

Updated: July 14, 2025

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