5 Oral Drugs Commonly Used in Sedation Dentistry

Published:
Updated:

Various oral sedatives have established efficacy and safety for managing fear and dental anxiety.

Anxiety and fear of going to the dentist persist despite the advancements in modern dentistry. Fortunately, oral sedatives in sedation dentistry have established efficacy and safety for managing dental anxiety. Oral sedatives can keep the patient awake while still having the desired calming effect.

local anesthetic allergies
Dr. Thoms and everyone of his staff members are incredible. I was warmly welcomed and made to feel comfortable and relaxed. Which is saying something as I had not been to the dentist in years due to fear/anxiety.
My procedure was clearly explained. The office staff was beyond helpful with payment and insurance.
The day of my appt was exactly as planned. We started ahead of schedule! The technicians and assistants were clearly skilled and again, helped ease my nervousness. We finished all work as planned. And then Dr. Thoms sat with me and my husband to discuss “everything.” He is very thorough. And finally one of his staff wheeled me down to the elevator, out across the parking lot, and helped me into my van. Now that is service!
Around 8:30 p.m. my cell phone rang and it was Dr. Thoms calling to check up on me. Wow!!!!! This man has all you could want in a dentist—kind, compassionate, thorough, understanding, excellent communicator, and skilled.
I cannot come up with the best words to so highly recommend the Dental Anesthesia Center. It was a remarkable, yet simple, but thorough experience for me.
If you are putting off going to the dentist and have anxiety or fears please call them. They will gently and competently take care of you.
And no, this is not an advertisement/ commercial—I am a real live (satisfied) patient.
The practice is top notch. Could not ask for better care.
Response from the owner:Thank you for your kind words! We’re grateful for your feedback and are proud to provide high-quality care in a supportive environment.
Great practice and nice people. I've been going there for 25+ years!!!
Response from the owner:Thank you for the kind review ! We appreciate that beyond words! It has been our pleasure having you as our patient! We look forward to seeing you at your next dental visit!
Dr. Hoffman and staff were patient and kind. They listened to health history that led to needing their services. They made the care plan individualized to specific needs. Appreciate all the team members!
Response from the owner:Thank you for your thoughtful review! We’re glad to hear that our team took the time to listen and provide compassionate, individualized care. We truly appreciate your kind words and your trust in our team.
What a wonderful, knowledgeable, caring staff. Excellent care given to our 26 year old special needs son. They made everything so easy and kept me updated through the whole visit. Would highly recommend.
Response from the owner:Thank you for your kind words and recommendation! Our team works hard to provide compassionate, high-quality care and to keep families informed every step of the way. We truly appreciate you taking the time to share your experience.

There are many types of sedation used in sedation dentistry, ranging from mild sedation administered through a breathing mask to general anesthesia administered intravenously. There is a range of oral sedatives between these two options that can keep the patient awake while still having the desired calming effect.

If you are not sure what substances are used during sedation dentistry, here is a list of the most common oral drugs that a sedation dentist may prescribe for your dental treatment.

Midazolam (Versed)

Midazolam is the most commonly used drug in oral sedation dentistry, and it is generally considered very safe, inducing only a mild form of sedation. One precaution usually required when administering midazolam is to reschedule patients with respiratory infections for the day of the intervention, as this drug has a greater impact on the respiratory tract than on the circulatory system.

Diazepam (Valium)

One of the drugs almost everyone has heard about is diazepam (Valium). It is used in various medical interventions, including as an oral sedative for dental surgery. The time it takes for diazepam to remain in a 50% concentration in the patient’s system is longer than with other drugs, making it the preferred choice for extended, complex dental operations.

Triazolam (Halcion)

For patients who have a hard time going to the dentist because of their associated anxiety, triazolam is often the doctor’s choice. Primarily a drug that fights insomnia, it has an effect on the patient’s anxiety level and helps them go through the procedure without remembering it afterward, which allows them to be unaffected by their dental anxiety and come back next time.

Lorazepam (Ativan)

Another benzodiazepine with amnesic properties, like diazepam, lorazepam is very useful in patients with anxiety, allowing them to go through their dental treatment without the effects of their anxiety.

Hydroxyzine (Vistaril)

Hydroxyzine is an antihistamine that also acts on the patient’s anxiety levels. It is used short-term to treat anxiety or help a patient feel sleepy or relaxed before a dental procedure.

As you can see, there are many drug options if your St. Louis sedation dentist recommends oral sedation for your dental procedure. Which drug will be chosen depends on how long it takes for the medicine to get out of your system, your allergies and sensitivities, and what is needed from the sedation itself.

St. Louis Sedation Dentistry

For over 30 years, the Dental Anesthesia Center has combined sleep dentistry and cutting-edge technology to help patients overcome the fear and health issues that have prevented them from seeking dental care. We work hard to make you feel at ease by providing exceptional patient care in a relaxed, convenient atmosphere.

Click here to learn more about Sedation Dentistry

Call Us Today

The first two board-certified Dentist Anesthesiologists in the state of Missouri.

Updated: July 14, 2025

Leave a Comment