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Is Laughing Gas Safe for Everyone?

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While nitrous oxide (also known as laughing gas) is generally safe, there are certain patients it is not recommended for.

Commonly known as laughing gas, nitrous oxide is a type of inhalation sedation that has been widely used in sedation dentistry since the 19th century when it was introduced to medicine. It is generally one of the safest substances that is used in sedation dentistry, as it’s effect doesn’t last long.

st. louis woman being sedated at dentist
We brought our 1.5 and 3.5 year old daughters here for cleaning / check ups. Our dental hygienist Laina was amazing...made them feel so comfortable. They had a great time and keep asking when they can go to the dentist again. Dr. Hoffman was great too and made everything super quick and not stressful. Great place for kids in addition to adults!
Every person in the office is so personable. That first off makes you comfortable. But then the methods used to clean my teeth, particularly. I don't feel a thing, and it's the first time in my life that I haven't. And I have a lot of anxiety about dental work, and I really do not feel a thing when my teeth are being cleaned
I came here with my 18 year old daughter who has an immense fear of Doctors and Dentist , The kindness and understanding without any judgement we received from Dr.Thom was just unbelievable. The work he did on my daughter was life changing for her . I would recommend him to anyone . Just amazing, kind talented Doctor.
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We met Dr. Shawn in Sept 2023 and in December, he removed our adult nonverbal son's wisdom teeth. Not gonna hold you, general anesthesia is billed incrementally (by the minute/quarter-hour) and is a heavy financial investment. I love this clinic because it really is a safe space for special needs families. There's a huge calm that accompanies knowing your dependent person is getting healthy. Dr. Shawn is exceptional. We drove 6 hours to get here so we'll choose a local practice for routine sedation cleanings down the road. I hope to see more neurodivergent acceptance built locally in our state's dentistry like this team has here. Meanwhile we are so grateful for this practice and grateful our son was in Dr. Shawn's care.
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Dr. Thoms and Robin are excellent in their care, concern, and support. Dr. Thoms explains everything and takes his time. If I have questions or concerns, he is easy to talk to and listens well.Robin is right there by my side throughout procedures. Her technical skills and professionalism are impressive. She is terrific!
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While it may seem perfectly harmless, laughing gas is still a sedative and should be taken only with a recommendation from your St. Louis sedation dentist, as it can have side effects when interacting with other medications or when administered to a person with an incompatible condition. That is why doctors choose the sedation option that is best for the patient instead of adapting the patient to the medication.

When Is Nitrous Oxide Recommended?

Laughing gas is often recommended when a patient has dentist anxiety or when he has to go through a long and tiring procedure. Sedation is an option also when the gag reflex is stronger than average or when the patient simply wants to make the treatment a bit easier to go through.

When it comes to patients that should not be put under stress, like patients with cardiac bypass or suffering from strong anxiety, administering nitrous oxide will generally make the dental procedure safer, as it takes away the associated stress.

Usually, young children that have to go through a dental procedure have trouble being still and patient for so long. Laughing gas can make the procedure possible.

Why It May Not Be Recommended

Although generally safe, there are times it should not be used. That’s why your St. Louis sedation dentist will check your medical history first before determining the best course of action.

Patients who have limited lung capacity or obstructive pulmonary disease should not be administered laughing gas. The safety of nitrous oxide is given by the fact that it acts quickly and wears out quickly as well. With these patients, however, the gas takes longer to act, as it is absorbed slower, and it leaves the body slowly as well. This greatly reduces the advantage of laughing gas has over other forms of sedation. 

Patients who have a stuffy nose and are forced to breathe through their mouths may not be good candidates for nitrous oxide either. Laughing gas is administered through nasal airways and it won’t be as effective if the patient cannot breathe well through their nose.

Patients who cough are also to be administered other kinds of sedatives.

Pregnant women should not be administered nitrous oxide unless it is an emergency and the amount of sedatives is approved by an obstetrician. The toxicity of nitrous oxide to multiplying cells can be a threat to the fetus, especially in the first weeks of pregnancy.

Patients with intracranial disorders shouldn’t be administered laughing gas, as it can increase the pressure levels in the skull.

Additionally, if you take certain medications or you use drugs, you need to specify this to your doctor before being given laughing gas, as they might interact badly and manifest side effects. 

Speak With The First Two Board Certified Dental Anesthesiologists in the State of Missouri

The bottom line is that it is extremely important to discuss all of your medical history with an experienced certified dental anesthesiologist before proceeding with treatment. To speak with the only certified dental anesthesiologists in the state of Missouri, call The Dental Anesthesia Center to day at (314) 862-7844.

Updated: March 28, 2025

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